The A66 is closed in both directions after a collision.
Cumbria police said it involved a car and a motorbike today Friday, September 27.
It happened near the Sportsman Inn.
Emergency services are currently at the scene. It is understood an air ambulance has been called.
The road is closed between the Troutbeck and Penruddock junctions.
Drivers are urged to avoid the area.
The incident was reported at 12.50pm.